• Profile

Study shows how E. coli causes urinary tract infections

IANS May 06, 2024

A team of scientists has found how the bacteria Escherichia coli, or E. coli can cause urinary tract infections (UTIs) in healthy people.

Women are more prone to UTIs than men and almost half of them are affected at some point in their lives with uncomfortable and often painful symptoms.

It usually occurs in the bladder or urethra, causing pelvic pain, increased urge to urinate, pain with urination and blood in the urine. It can also lead to serious infections in the kidney causing back pain, nausea, vomiting and fever.

The study published in the journal PNAS examined how E. coli uses host nutrients to reproduce at an extraordinarily rapid pace during an infection.

The team from the University of Michigan in the US used an experimental model to decode the bacteria's mechanism.

They identified bacterial genes that may be important for establishing infection by looking at mutant strains that were not as good at replicating in the experimental models.

The team found a group of genes controlling transport systems, which if inhibited can help stop the rapid growth of E.coli.

"When bacteria need something to grow, say an amino acid, they can get it in two ways," said Harry Mobley, Professor of Microbiology and Immunology at the University’s Medical School

"They can make it, or they can steal it from their host using what we call a transport system," he added.

Further, the team also found a type of transporter called ABC (for ATP-binding cassette) that is essential for infection.

"Many bacteria strains lacking these nutrient import systems were defective for growth on bladder and kidney," the team said.

The findings open avenues for the development of new therapeutics -- which is especially important in an era of increasing antibiotic resistance.

Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
M3 app logo
Choose easy access to M3 India from your mobile!

M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen