Vanner EA, Sun CQ, McSoley MJ, et al. - In the present study, the researchers sought to compare one-year results for the composite treatment outcome from the Tube Versus Trabeculectomy (TVT) Randomized Controlled Trial (RCT) to those from an Intelligent Research In Sight (IRIS) Registry cohort of analogous eyes. After a previous trabeculectomy and/or cataract extraction, eyes in the IRIS Registry obtained either a glaucoma drainage implant (tube) or trabeculectomy, with data for one-year follow-up analyses. The TVT IRIS Registry cohort involved 419 eyes, 236 tube eyes (56.3%) and 183 trabeculectomy eyes (43.7%). There was no significant failure risk difference in this cohort. The findings were not the same as the TVT RCT. Non-Baerveldt tubes, higher severity among tube eyes, and practice trends that represent real-world data, which vary from RCTs, are all possible explanations.