Asbell PA, Sanfilippo CM, Sahm DF, et al. - Researchers conducted this cross-sectional study to evaluate overall antibiotic resistance profiles and trends among bacterial isolates from ocular sources collected during 10 years. In total, 6,091 isolates (2,189 S aureus, 1,765 CoNS, 590 S pneumoniae, 767 P aeruginosa, and 780 H influenzae) were obtained from 88 sites (47 community hospitals, 29 academic or university hospitals, 9 specialty or ocular centers, and 3 reference laboratories) across 41 states (2526 Midwest, 1300 Northeast, 783 South, and 1482 West). Of 6,091 individuals from whom isolates were obtained, 2,735 (44.9%) were male, 2,851 (46.8%) were female, and 505 (8.3%) did not report gender. The results indicate that in the United States, methicillin resistance and multidrug resistance is prevalent among ocular S aureus and CoNS isolates, and should be considered considered in the treatment of staphylococcal ocular infections, particularly in older people. The small declines in antibiotic resistance among S aureus isolates are encouraging but further monitoring is needed.