Mori L, Signori A, Prada V, et al. - Because muscle-strengthening, stretching or proprioceptive treatments can slow the progression of symptoms in Charcot—Marie–Tooth (CMT) neuropathy, researchers conducted this multicenter, prospective, randomized, single-blind, controlled study to assess safety and effectiveness of treadmill training in CMT1A. They enlisted 53 CMT1A-affected outpatients and randomized them into two treatment groups: one was treated with stretching and proprioceptive exercise, while the other was treated with treadmill training. All candidates were evaluated at baseline and after 3 and 6 months of treatment. After 3 months and 6 months of treatment, most patients exhibited an improvement in at least one outcome measure. There have been no reported adverse events in either group. The most significant finding was that both stretching and proprioceptive exercise, as well as treadmill training had an objective benefit for patients affected by CMT disease without causing overwork weakness. They had a low rate of drop out and found no deterioration in motor performance. The findings also verify that the right way to assess the effectiveness of a treatment is to apply evidence-based medicine methods to rehabilitative studies.