Peterson E, Lo KB, DeJoy RI, et al. - The present study was performed to explore the impact of both cardiac and noncardiac comorbidities on a high-risk population with COVID-19 infection and coronary artery disease (CAD) compared to those without CAD. Researchers conducted a retrospective study of patients who tested COVID-19 positive via reverse transcriptase-PCR assay to compare the characteristics and outcomes of patients with and without CAD. They obtained and analyzed population demographics, comorbidities and clinical outcomes. They used multivariate logistic regression analysis to distinguish factors associated with inpatient mortality. They distinguished a final sample population of 355 patients, 77 of which had a known diagnosis of coronary artery disease. The results showed that individuals with CAD and COVID-19 have higher rates of comorbidities, inpatient mortality and need for renal replacement therapy compared to their non-CAD counterparts. Nevertheless, CAD in itself was not correlated with mortality after adjusting for other covariates, implying that other factors may play a larger role in the increased mortality and poor outcomes in these patients.