Ong SS, et al. - Researchers compared children with sickle cell disease (SCD) vs age- and race-matched controls concerning the severity of macular vascular changes. In this cross-sectional study, they included 34 HbSS, 34 HbS variant (Goldberg staging 0-3 for SCD eyes), and 24 control eyes (total 48 children, aged 5-17 years). Optical coherence tomography angiography (OCTA) scans centered on the fovea and temporal macula was performed and measurement of retinal thickness, superficial capillary plexus, and deep capillary plexus vessel density, and foveal avascular zone size were done in all included individuals. As per findings, children with SCD vs age and race-matched controls exhibit similar retinal thickness but less dense vasculature on OCTA. This infers that microvascular insult may precede structural thinning.