Poudel B, et al. - Researchers examined data from 717 Coronary Artery Risk Development in Young Adults study participants and used thresholds from the 2017 American College of Cardiology/American Heart Association (ACC/AHA) and the Seventh Report of the Joint National Committee (JNC7) guidelines for comparison of the prevalence of clinic and out-of-clinic blood pressure (BP) phenotypes, given that hypertension-defining BP thresholds were lowered in the former vs the latter. Among participants not taking antihypertensive medication and per the JNC7 and 2017 ACC/AHA guidelines, 11.1% and 30.1% of participants had clinic hypertension, 37.5% and 57.9% had awake hypertension, 35.7% and 58.1% had asleep hypertension, and 35.7% and 58.6% had 24-hour hypertension, respectively. Furthermore, according to these same guideline definitions, 1.9% and 3.2% had white-coat hypertension, 28.2% and 31.0% had masked hypertension, and 9.3% and 26.9% had sustained hypertension, respectively. Among participants taking antihypertensive medication—and when defined according to the JNC7 and 2017 ACC/AHA guideline BP thresholds—18.6% and 45.3% had uncontrolled clinic BP, 48.1% and 62.5% had uncontrolled awake BP, 48.1% and 70.2% had uncontrolled asleep BP and, 47.7% and 65.3% had uncontrolled 24-hour BP, respectively. By criteria from the JNC7 and 2017 ACC/AHA guideline BP thresholds, the prevalence was 1.4% and 5.2% for white-coat effect, 30.9% and 22.5% for masked uncontrolled hypertension, and 17.2% and 40.0% for sustained uncontrolled BP, respectively. Overall, a substantially higher prevalence of awake, asleep, 24-hour, and sustained hypertension was reported using the 2017 ACC/AHA guideline in this study.