Koo EH, Eghrari AO, Dzhaber D, et al. - In this prospective cross-sectional study, experts aspired to explore whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is detectable in the aqueous of asymptomatic individuals presenting for ophthalmic surgery. All patients undergoing anterior segment surgery at an Ambulatory Surgical Center affiliated with a tertiary academic center in South Florida between June and September 2020 received SARS-CoV-2 nasal swab testing and a relevant review of symptoms prior to surgery, with negative results required for both to proceed with surgery. Twenty-nine of the 70 samples collected had insufficient volume and could not be analyzed. The presence of SARS-CoV-2 viral RNA in aqueous despite negative nasal swab testing confirms the virus's presence beyond the blood-ocular barrier in asymptomatic people and increases the possibility that the virus may persist in immunoprivileged spaces despite a lack of symptoms.