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Predictive value of pretreatment lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio in the survival of nasopharyngeal carcinoma patients

Cancer Management and Research Nov 25, 2021

Chen Y, Sun J, Hu D, et al. - Survival in nasopharyngeal carcinoma (NPC) can be predicted by using the index lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR).

  • In this retrospective study of 216 patients with NPC, predictive value of some indexes in the survival of NPC was assessed; receiver operating characteristic curve was applied.

  • Poor overall survival (OS) was observed in relation to neutrophil-to-lymphocyte ratio (NLR) ≤ 2.695 and PLR ≤ 140.065; however, the LMR and systemic inflammatory response index (SIRI) displayed no significant statistical significance.

  • NLR ≤ 2.045 and PLR ≤ 125.605 were related to poor regional recurrence-free survival, LMR ≤ 2.535 and PLR ≤ 140.065 were linked with poor distant metastasis-free survival (DMFS), NLR ≤ 2.125 and PLR ≤ 132.645 were related to poor locoregional recurrence-free survival, respectively.

  • In logistic regression analysis, low LMR (≤ 2.535) was significantly inferior in OS (HR 23.085) and DMFS (HR 22.839).

  • Moreover, a significant association of low PLR (≤ 140.065) with worse OS (HR 11.908) and DMFS (HR 9.556) was found.

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