Kendler KS, et al. - Researchers followed 7,606 individuals with a registration of substance-induced psychotic disorder between 1997 and 2015 in national medical registries for up to a mean duration of 84 months in order to ascertain the etiology of substance-induced psychotic disorder and its progression to schizophrenia. Substantial drug exposure among individuals at high familial risk for substance abuse and moderately elevated familial risk for psychosis seemed to result in substance-induced psychotic disorder. Progression from substance-induced psychosis to schizophrenia seemed to be related to familial risk for psychosis, but not to substance abuse. In highly vulnerable individuals, schizophrenia following substance-induced psychosis may be a drug-precipitated disorder—not a syndrome predominantly caused by drug exposure.