• Profile
Close

Neoadjuvant nivolumab and chemotherapy in patients with locally advanced non- small cell lung cancer: A retrospective study

Cancer Management and Research Feb 15, 2022

Based on the findings, nivolumab in combination with paclitaxel and carboplatin could serve as a potential neoadjuvant regimen for treating locally advanced non-small cell lung cancer (NSCLC).

  • Immune checkpoint inhibitors have demonstrated survival benefit in metastatic NSCLC.

  • This is a retrospective analysis of patients with locally advanced NSCLC receiving neoadjuvant nivolumab and chemotherapy (paclitaxel with carboplatin) followed by surgery.

  • Neoadjuvant therapy was received by overall 46 eligible patients; good tolerability of the treatment was evident with just 7 (15.2%) typical immune-related adverse events (hyperthyroidism, hyperglycemia, and rash) documented.

  • Surgical resection was performed in 45 cases, and a R0 resection was achieved in 43 (95.6%) of them.

  • A complete response, partial response, stable disease, and progressive disease was evident in 2 (4.3%), 26 (56.5%), 17 (37.0%), 6 (26.1%), and 1 (2.2%) patients.

  • A major pathological response and a pathological complete response was obtained in 8 (17.4%) and 24 (52.2%) patients, respectively.

  • A median follow-up of 15.5 months revealed absence of progression in 27 (60%) of 45 patients who had tumor resection.

  • A progression-free survival of 45.8% and overall survival of 79.9% was achieved at 24 months.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay