Vordenbaumen S, Sokolowski A, Rosenbaum A, et al. - This study was undertaken to investigate the possible relationships of dietary methyl donors and products with CD40L methylation status in systemic lupus erythematosus (SLE). Researchers used food frequency questionnaires to estimate methyl donor micronutrients in 61 female SLE patients (age 45.7 ± 12.0 years, disease duration 16.2 ± 8.4 years) and compared to methylation levels of previously distinguished key DNA methylation sites (CpG17 and CpG22) within CD40L promotor of T-cells using quantitative DNA methylation analysis on the EpiTYPER mass spectrometry platform. They evaluated disease activity by SLE Disease Activity Index. They applied linear regression modelling. The outcomes suggested that the dietary methyl donors may influence DNA methylation levels and thereby disease activity in SLE.