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Male pituitary–gonadal axis dysfunction in post‐acute COVID‐19 syndrome—prevalence and associated factors: A Mediterranean case series

Clinical Endocrinology Jul 28, 2021

Moreno-Perez O, Merino E, Alfayate R, et al. - Researchers herein investigated the prevalence of low serum testosterone (LT; this is defined as total testosterone (TT) < 2 ng/ml or if TT levels 2–4 ng/ml as calculated free testosterone < 6.36 ng/dl) and impaired fertility potential [Leydig and Sertoli cells dysfunction (Inhibin-B < 89 pg/ml defined sertoli cell dysfunction), respectively] in coronavirus disease 2019 (COVID-19) male survivors, as well as investigated acute infection-related linked factors. In addition, they examined its correlation with post-acute COVID-19 syndrome (PCS) and quality of life (QOL). Evaluation was performed including 143 patients at a median (interquartile range) of 77 days (72–83) after disease onset; 72% of them recovered from severe pneumonia. Findings revealed a high prevalence of male LT and impaired fertility potential in COVID-19 survivors in the medium term; LT was identified in 41 patients (28.7%) and low levels of inhibin-B were detected in 25 patients (18.1%). After multivariate adjustment, they observed correlation of obesity and hypokalaemia with LT, whereas there was an independent predictive value of age more than 65 for Sertoli cell dysfunction. No association of LT or Sertoli cell dysfunction with PCS was observed. Patients with LT had a lower score in four domains of QOL as evaluated by SF-36 v.2 .

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