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Long-term follow-up of nailfold videocapillaroscopic changes in dermatomyositis vs systemic sclerosis patients

Clinical Rheumatology Sep 15, 2018

Pizzorni C, et al. - In this retrospective study, researchers identified changes in nailfold videocapillaroscopy (NVC) in patients with dermatomyositis (DM) during a 3-year follow-up and compared the NVC findings between DM and systemic sclerosis (SSc) patients at their first visit. This pilot study showed, for the first time, that the capillaroscopic manifestations of DM persist over long-term, vs the progressive changes described in SSc patients; the anti-Jo-1 positivity did not seem to modify the NVC pattern. The giant capillary and microhemorrhage scores were significantly higher in SSc vs those in DM patients, while capillary density, ramification (abnormally shaped capillaries, expression of angiogenesis), and disorganization scores were higher in DM patients, when comparing baseline DM with SSc patients. It was noted that the absolute number of ramified capillaries was significantly higher in DM patients. On the other hand, the absolute capillary number was significantly higher in SSc patients at baseline.

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