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Long-term benzodiazepine prescription during maintenance therapy of individuals with psychosis spectrum disorders—associations with cognition and global functioning

Clinical Neuropharmacology May 28, 2021

Savic B, Jerotic S, ; Ristic I, et al. - In this study, the relationship between long-term benzodiazepine (BZD) prescription, global functioning, and cognitive functioning in persons with psychosis spectrum disorder (PSD) was investigated. Researchers conducted an exploratory study including a total of 55 PSD patients, recruited from 2 outpatient services in Serbia. They used the Brief Psychiatric Rating Scale for symptom assessment, functioning was assessed by Global Assessment and Functioning Scale, and cognition was measured by the Global Assessment of Functioning–Cognition in Schizophrenia Scale. The research evaluated a topic that continues to be under-researched, particularly in the Balkans. There is a need for prospective studies and comprehensive cognitive batteries to further elucidate the relationships between polypharmacy, long-term BZD use, cognitive functioning, and global functioning during maintenance therapy of individuals with PSD.

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