Lopez-Nunez O, John I, Panasiti RN, et al. - Archival files from two large pediatric institutions and a tumor registry were investigated for pediatric inflammatory myofibroblastic tumors in order to ascertain clinicopathological and molecular characterization of infantile inflammatory myofibroblastic tumors in 12 cases. Kinase fusions including ALK, ROS1, and NTRK3 including three novel fusion partners (KLC1, FN1, and RBPMS, respectively) were harbored by each tumor. A favorable response to crizotinib observed in three cases encourages its possible use in kids as noted in elderly people. Thus, for relevant diagnosis and optimized targeted therapy, awareness of these unusual morphologic, immunophenotypic, and molecular characteristics is crucial.