Grilo CM, et al. - As available evidence-based psychological interventions do not produce sufficient benefit in a substantial proportion of patients with binge-eating disorder (BED), researchers herein aimed at examining depression scores as predictors and moderators of response to cognitive-behavioral therapy (CBT) and behavioral weight-loss (BWL) for BED. They investigated if changes in depression scores correlate with changes in treatment outcomes. They randomized 90 adults with BED with obesity to CBT or BWL (6 months) and evaluated them independently throughout treatment, at post treatment, and 12-month follow-up after treatments (18 months post-randomization). Depression scores were not identified to be either predictive of or moderating acute- or longer-term outcomes in patients with BED undergoing CBT or BWL. Findings emphasize the necessity for improving treatments for BED overall, although they support that patients with raised depression scores derive benefits from existing CBT and BWL interventions.