Colijn JM, Liefers B, Joachim N, et al. - Researchers conducted the study for determining long-term enlargement of geographic atrophy (GA). In this investigation, participant data were obtained from 4 population-based cohort studies, with up to 25 years of follow-up and eye examinations at 5-year intervals: the Rotterdam Study cohorts 1, 2, and 3 and the Blue Mountains Eye Study. Of the 171 patients who were included, 106 (62.0%) were female, and the mean (SD) age at inclusion was 82.6 (7.1) years. In total, 147 of 242 eyes with GA (60.7%) were newly diagnosed in the study. The enlargement of GA in the general population appeared to be highly variable in this study. At first presentation, more than one-third of incident GA was foveal; those with extrafoveal GA developed foveal GA after a mean of 5.6 years. Future intervention trials should prioritise patients with a high risk of severe visual decline within their life expectancy.