Carmi L, et al. - Recently a dysfunction of the cortical-striatal-thalamic-cortical circuit has been thought to play a role in obsessive-compulsive disorder (OCD) and a prior feasibility study proposed a benefit targeting the medial prefrontal cortex and the anterior cingulate cortex with deep transcranial magnetic stimulation (dTMS), so researchers conducted this multicenter double-blind sham-controlled study investigating the therapeutic effect of dTMS in these patients. Random allocation of 99 OCD patients to treatment with either high-frequency (20 Hz) or sham dTMS was done at 11 centers. For 6 weeks, patients received daily treatments following individualized symptom provocation. At the 1-month follow-up, the active treatment group exhibited response rates of 45.2% and the sham treatment group exhibited response rates of 17.8%. OCD symptoms could be significantly improved with high-frequency dTMS over the medial prefrontal cortex and anterior cingulate cortex and for those who do not respond sufficiently to pharmacological and psychological interventions, it could be considered as a potential intervention.