Andringa A, et al. - Using the ICF classification, researchers provided a comprehensive overview of reported effects and scientific robustness of botulinum toxin (BoNT) treatment with respect to the main clinical goals related to post-stroke upper limb spasticity. From inception to mid-May 2018, they searched Embase, PubMed, Wiley/Cochrane Library, and Ebsco/CINAHL databases for relevant studies. They found that BoNT significantly decreased involuntary movements, spasticity-related pain, and carer burden, and improved passive range of motion, while after intervention no evidence was found for arm and hand use. Given the robustness of the current evidence, it is not necessary to investigate BoNT for its favorable effects on the resistance to passive movement of the spastic wrist and fingers and self-care. The authors concluded that no studies are required to further confirm the lack of effects of BoNT on arm-hand capacity; however, further investigation is warranted determine the proposed favorable effects of BoNT on other body functions, which may lead to clinically significant results at levels of activity and participation.