López-Padrós C, Salord N, Alves C, et al. - Among 42 patients [mean age was 49(6.7) years, body mass index 35(2.7) kg/m² and apnea-hypopnea index 69(20) events/h] with obesity and severe obstructive sleep apnoea (OSA) undergoing continuous positive airway pressure treatment, researchers ascertained if an intensive weight-loss program (IWLP) is effective for reducing weight, the severity of OSA and metabolic variables. Study participants were randomized to the control (CG,n = 20) or the intervention group (IG,n = 22), who followed a 12-month IWLP. According to this randomized controlled trial, the IG demonstrated a decline in C-reactive protein, glycated hemoglobin and an increase in high-density lipoprotein cholesterol at 12 months. It was concluded that an IWLP is effective for weight reduction and OSA severity in patients with obesity and severe OSA. In addition, it leads to better lipid profiles, glycemic control, and inflammatory markers.