Korgavkar K, et al. - This study gauged the efficacy of topical fluorouracil, 5%, cream on photoaging using validated photonumeric scales. No improvements were reported in photoaging with a standard course of topical fluorouracil, 5%, cream. This could be due to a true lack of effect in photodamage or limitations of the photonumeric scales in capturing the effect. The development of photonumeric scales encompassing the manifestations of photoaging other than rhytids, such as lentigines, hyperpigmentation, and telangiectasias, ought to be taken into account.