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Effect of a hypocaloric, nutritionally complete, higher-protein meal plan on bone density and quality in older adults with obesity: A randomized trial

American Journal of Clinical Nutrition Jan 20, 2019

Weaver AA, et al. – In this study involving 96 older obese adults (aged 70.3 ± 3.7 years; BMI: 35.4 ± 3.3 kg/m2), researchers compared the change in bone density and quality after random assignment to a 6-month hypocaloric, nutritionally complete, higher-protein meal plan targeting ≥ 1.0-g protein · kg body weight–1 · d–1 (weight-loss group; n= 47) or to a weight-stability (WS) group targeting 0.8-g protein · kg body weight–1 · d–1, the current Recommended Dietary Allowance (n=49). Using dual-energy X-ray absorptiometry, they assessed total hip bone mineral density (BMD) as the primary outcome; femoral neck BMD, lumbar spine BMD, and lumbar spine trabecular bone score (TBS) were assessed as secondary outcomes. All outcomes were assessed at baseline, 3 months, and 6 months. At baseline, the measured total hip, femoral neck, and lumbar spine BMDs were 1.016 ± 0.160, 0.941 ± 0.142, and 1.287 ± 0.246 g/cm2, respectively; lumbar TBS was 1.398 ± 0.109. Compared with weight-stable controls, similar bone density and quality were maintained among older adults who followed a hypocaloric, nutritionally complete, higher-protein meal plan. This dietary intervention did not result in loss of hip and spine bone density in older adults and could improve bone quality.

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