Tai V, Narang RK, Gamble G, et al. - In order to find out whether urate-associated genetic variants differ in their influence on gout risk according to BMI, researchers recruited a total of 358,728 individuals from the UK Biobank Resource. This study categorized individuals into three BMI groups (BMI<25kg/m2 [low/normal], 25kg/m2≤BMI<30kg/m2 [overweight], and BMI≥30kg/m2 [obese]). Using a urate genetic risk score (GRS), BMI interactions for gout relationships were examined by logistic regression. The prevalence of gout was higher in those with a GRS ≥ mean in the low/normal BMI group (0.27% vs 0.77%), overweight BMI group (1.02% vs 3.02%), and obese BMI group (2.49% vs 6.23%), compared with individuals with a GRS < mean. Compared with those with a GRS < mean, in the low/normal BMI group (OR [95% CI] 2.89 [2.42-3.47]), overweight BMI group (3.09 [2.84-3.36]), and obese BMI group (2.65 [2.46-2.86]), they found a positive relationship between GRS ≥ mean and gout. Compared with overweight, the relationship of a urate genetic risk score for gout is mildly attenuated in individuals with obesity. Nevertheless, genetic variants have a strong impact on gout risk in those with overweight and obese BMI, with a similar influence to that seen with low/normal BMI.