Gautvik KM, Günther CC, Prijatelj V, et al. - In the present study, the researchers sought to examine mechanisms resulting in low BMD and susceptibility to fracture by comparing noncoding RNAs (ncRNAs) in biopsies of non–weight-bearing (NWB) iliac (n = 84) and weight bearing (WB) femoral (n = 18) postmenopausal bone across BMDs varying from normal (T-score > −1.0) to osteoporotic (T-score ≤ −2.5). Using linear and logistic regression and least absolute shrinkage and selection operator (Lasso) analysis, association with BMD or fracture, adjusted by age and body mass index, were calculated. According to findings, 28 iliac ncRNAs were linked to the risk of fracture. The authors identified functional bone ncRNAs related to fracture and BMD in this comprehensive investigation of the skeletal genetic background in postmenopausal women, representing distinct subsets in WB and NWB skeletal sites.