Wan Y, Tabung FK, Lee DH, et al. - Findings revealed elevated risk of all-cause, cardiovascular disease (CVD), and cancer mortality in relation to higher insulinemic potential of diet. To enhance overall health and avert premature death, adopting a diet with low insulinemic potential might represent an effective strategy.

• A total of 63,464 women from the Nurses' Health Study (1986–2016) and 42,880 men from the Health Professionals Follow-up Study (1986–2016) were prospectively followed to determine if insulinemic potential of diet is related to risk of all-cause and cause-specific mortality.

• A higher dietary insulinemic potential was shown to be linked with an elevated risk of death from all-cause (hazard ratio [HR] comparing extreme quintiles: 1.33; 95% CI 1.29, 1.38; P-trend <0.001), CVD (HR 1.37; 95% CI 1.27, 1.46; P-trend <0.001), and cancers (HR 1.20; 95% CI 1.13, 1.28; P-trend<0.001), in the pooled multivariable-adjusted analyses.

• These links were independent of BMI and continued to be significant post-further adjustment for other well-known dietary indices.

• In addition, a higher subsequent risk of all-cause (HR 1.13; 95% CI 1.09, 1.18; P-trend<0.001) and CVD (HR 1.10; 95% CI 1.01, 1.21; P-trend = 0.006) mortality was found in participants with the greatest increases in EDIH (empirical dietary index for hyperinsulinemia) scores over an 8-year period vs those whose EDIH scores were stable.