Fiorentini C, Bedini A, Mandel VD, et al. - Given that the duration of perioperative antibiotic treatment in skin reconstruction with dermal substitutes is not well known, researchers contrasted the incidence of infective complications after two different durations of perioperative antibiotic treatment in patients undergoing surgical reconstruction with skin dermal substitutes (SDS) after excision of skin cancer. Of 116 individuals undergoing SDS surgical reconstruction, 62 received an extended schedule, and 54 received a short schedule. Overall infection incidence rate was 20.7%. In comparison with patients undergoing SDS reconstruction in the chest/head, those undergoing SDS reconstruction in the limb/foot had a higher risk of infection. The short protocol has been shown to be effective for patients undergoing surgical reconstruction with SDS. A ≤ 24‐hour perioperative antibiotic schedule did not increase the rate of infection, potentially leading to a reduction in antibiotic exposure.