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Clinicopathological factors associated with death from thin (≤ 1.00 mm) melanoma

British Journal of Dermatology Oct 03, 2019

Claeson M, Baade P, Brown S, et al. - Since thin cutaneous melanomas (≤ 1.00 mm) were increasing worldwide, causing around a quarter of all melanoma deaths in the USA and Australia, researchers conducted this large, nested case-case study to identify clinicopathological factors correlated with fatal thin melanomas. This investigation extracted data from the population-based Queensland Cancer Registry, Australia. Participants (n = 27,660) in the study were Queensland residents (aged 0 to 89 years) who were diagnosed with a single, locally invasive thin melanoma (≤ 1.00 mm) between 1995 and 2014. There were 424 fatal cases and 1,189 non-fatal cases in the final case series. Scalp location is a powerful thin melanoma death prognostic factor. Furthermore, this study provides the support that the more hazardous thin lesions are melanomas with a thickness of 0.80-1.00 mm. During follow-up, patients with these tumour features require special attention.
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