Verhoef EI, et al. - Authors pursued a comparison of the clinicopathological characteristics and outcome of men with overall biopsy GS 3 + 4 = 7 with highest GS 3 + 4 = 7 (HI = OV) to those with highest GS > 3 + 4 = 7 (HI > OV) in subjects with prostate cancer. Individuals with highest GS > 3 + 4 = 7 reported worse clinicopathological features among patients with overall GS 3 + 4 = 7. However, clinical outcome did not appear to be statistically significant. Hence, yielded data justified the use of overall GS than of highest GS for clinical decision-making, potentially preventing overtreatment in prostate cancer patients.