Stolnicu S, et al. - Researchers aimed to redefine adenosquamous carcinomas, considering the ambiguous etiologic, morphological, and clinical features and outcomes related to these tumors. On reviewing 59 initially diagnosed adenosquamous carcinomas (including glassy cell carcinoma and related lesions) and performing immunohistochemical profiling, as well as human papillomavirus (HPV) testing by in situ hybridization on select cases, 34 retained their adenosquamous carcinoma diagnosis, 9 were reclassified as pure invasive stratified mucin-producing carcinomas, 10 as invasive stratified mucin-producing carcinomas with other components (such as HPV-associated mucinous, usual-type, or adenosquamous carcinomas), and 4 as HPV-associated usual or mucinous adenocarcinomas with benign-appearing squamous metaplasia. All groups displayed comparable survival outcomes. They recommend diagnosing adenosquamous carcinomas only in the presence of unequivocal malignant glandular and squamous differentiation. Criteria for adenosquamous carcinoma was not met by the two putative glassy cell carcinomas, and thus reconsideration should be given to how they are categorized.