Xiang M, et al. - The most common category of chronic cutaneous lupus erythematosus is discoid lupus erythematosus (DLE), where the pathological process is reported to be closely linked with immunity. Researchers conducted this bioinformatic analysis with the aim to determine key biomarkers and to perform immune infiltration analysis in the skin biopsy samples of DLE. They employed GSE120809, GSE100093, GSE72535, GSE81071 to retrieve data concerning gene expression profiles, altogether containing 79 DLE samples and 47 normal controls (NC). Of 391 identified DEGs, 57 were up-regulated genes and 334 were down-regulated genes. GO and KEGG enrichment analyses revealed close correlation of DEGs with different steps in the immune response. Following were the top 10 hub genes: GBP2, HLA-F, IFIT2, RSAD2, ISG15, IFIT1, IFIT3, MX1, XAF1 and IFI6. In Immune filtration analysis from CIBERSORT, DLE samples exhibited higher percentages of CD8+ T cells, T cells CD4 memory activated, T cells gamma delta, macrophages M1 and lower percentages of T cells regulatory, macrophages M2, dendritic cells resting, mast cells resting, mast cells activated when compared with NC. From the contrast between DLE and NC skin samples, key biomarkers were selected in this bioinformatic study; this study is identified to be the first research to analyze immune cell filtration in DLE.