Vordenbäumen S, Vordenbäumen A, Gebhard C, et al. - This study was undertaken to investigate the relationships of site-specific CD4+-T-cell hypomethylation of the CD40-Ligand gene (CD40L) with disease activity of women with systemic lupus erythematosus (SLE). Researchers included 60 female SLE individuals who participated in the study (age 45.7 ± 11.1 years, disease duration 17.0 ± 8.3 years). It was shown that site-specific hypomethylation of the CD40L promoter in CD4+-T-cells exhibit relationships with disease activity in female SLE patients.