Association of iron deficiency with incident cardiovascular diseases and mortality in the general population
ESC Heart Failure Oct 11, 2021
Schrage B, Rübsamen N, Ojeda FM, et al. - Findings imply that functional iron deficiency (FID) represents a relevant risk factor for cardiovascular (CV) diseases in the general population.
This study included 12,164 individuals from three European population-based cohorts.
Absolute iron deficiency (AID) was described as ferritin < 100 μg/L or as ferritin < 30 μg/L (severe AID), and FID was defined as ferritin < 100 μg/L or ferritin 100–299 μg/L and transferrin saturation < 20%.
A high prevalence of FID was evident (64.3%).
FID was related to incident coronary heart disease (CHD) [hazard ratio (HR) 1.24], CV mortality (HR 1.26), and all-cause mortality (HR 1.12), and had the highest population attributable fraction for these events.
An association of AID with CHD (HR 1.20) but not with mortality was evident.
Severe AID was only linked with all-cause death (HR 1.28).
FID accounted for 5.4% of all deaths, 11.7% of all CV deaths, and 10.7% of CHD.
Exclusive Write-ups & Webinars by KOLs
Daily Quiz by specialty
Paid Market Research Surveys
Case discussions, News & Journals' summaries