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Association of iron deficiency with incident cardiovascular diseases and mortality in the general population

ESC Heart Failure Oct 11, 2021

Schrage B, Rübsamen N, Ojeda FM, et al. - Findings imply that functional iron deficiency (FID) represents a relevant risk factor for cardiovascular (CV) diseases in the general population.

  • This study included 12,164 individuals from three European population-based cohorts.

  • Absolute iron deficiency (AID) was described as ferritin < 100 μg/L or as ferritin < 30 μg/L (severe AID), and FID was defined as ferritin < 100 μg/L or ferritin 100–299 μg/L and transferrin saturation < 20%.

  • A high prevalence of FID was evident (64.3%).

  • FID was related to incident coronary heart disease (CHD) [hazard ratio (HR) 1.24], CV mortality (HR 1.26), and all-cause mortality (HR 1.12), and had the highest population attributable fraction for these events.

  • An association of AID with CHD (HR 1.20) but not with mortality was evident.

  • Severe AID was only linked with all-cause death (HR 1.28).

  • FID accounted for 5.4% of all deaths, 11.7% of all CV deaths, and 10.7% of CHD.

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