Pase MP, Himali JJ, Beiser AS, et al. - Utilizing prospective community-based Framingham Heart Study (FHS) and Cardiovascular Health Study (CHS) cohorts, experts aspired to explore whether the inflammatory marker plasma soluble CD14 (sCD14) correlates with incident dementia and related endophenotypes in two community-based cohorts. The sample consisted of 1,588 candidates from the FHS (mean age 69 ± 6 years, 47% male, 131 incident events) and 3,129 candidates from the CHS (mean age 72 ± 5 years, 41% male, 724 incident events) for the risk of incident dementia. Findings suggested an association of higher levels of sCD14 with various cognitive and MRI markers of accelerated brain aging in both cohorts and with a greater progression of brain atrophy and a reduction in executive function in the FHS. The authors concluded that sCD14 is an inflammatory marker associated with brain atrophy, cognitive decline, and incident dementia.