Association of antiparietal cell and anti-intrinsic factor antibodies with risk of gastric cancer
JAMA Dec 22, 2021
Song M, Camargo MC, Katki HA, et al. - With the waning prevalence of Helicobacter pylori, autoimmune-driven gastric cancer (GC) could explain the recent increase of GC incidence among the younger women.
This cohort study included 529 female matched pairs from the Finnish Maternity Cohort and 457 male matched pairs from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, to investigate whether an association exists between autoantibodies to gastric mucosa and GC.
An association between prediagnostic seropositivity to antiparietal cell antibodies and an increased risk of GC was found in young women born in 1938 through 1989 during a median of 17 years follow-up but not in older men born in 1916 through 1939 during a median of 11 years observation.
The magnitude of association was identified to be stronger in Helicobacter pylori–seronegative females and most pronounced for tumors in the corpus.
Findings show that autoantibody positivity could reflect subclinical autoimmune gastritis in younger females.
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