Pandya C, et al. - Using a cross-sectional design, researchers assessed the independent link between symptom burden and physical function impairment in patients with cancer (aged ≥ 65 years) assessed by geriatric assessment. They noted a higher prevalence of instrumental activities of daily living (IADL) impairment, physical activity limitation, falls, and Short Physical Performance Battery score of ≤ 9 in patients in the highest quartile of symptom burden vs those in the bottom quartile. An increase in the odds of having IADL impairment, physical activity limitations, falls, and SPPB scores of ≤ 9 by 4.8%, 4.4%, 2.9%, and 2.5%, respectively, was observed in relation to each unit increase in Clinical Symptom Inventory score. Overall, a link was evident between higher symptom burden and functional impairment in older patients with cancer.