Lancour D, Dupuis J, Mayeux R, et al. - Since the identifying and understanding the functional role of genetic risk factors for Alzheimer disease (AD) has been complicated by the variability of genetic influences across brain regions and confounding with age-related neurodegeneration, researchers applied an integrative network strategy to capture complex connections between RAD genes across the relevant regions of the brain and to help the discovery of novel AD-related genes. A gene co-expression network was developed in six people using data obtained from the Allen Brain Atlas for multiple brain regions (cerebral cortex, cerebellum, and brain stem). The results suggest that risk factors associated with AD are potentially linked to brain region-specific effects on gene expression, which can be identified via a gene network approach.