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A prospective study of long-term outcomes among hospitalized COVID-19 patients with and without neurological complications

Journal of the Neurological Sciences May 16, 2021

Frontera JA, Yang D, Lewis A, et al. - Experts aspired to explore whether long-term functional outcomes would be worse among patients with neurological complications compared with age, gender and severity of illness-matched COVID-19 controls without neurological complications. They carried out a prospective, observational study of consecutive COVID-19 patients hospitalized at four New York City area hospitals within the same hospital system between March 10, 2020, and May 20, 2020. Three hundred ninety-five (65%) of 606 hospitalised COVID-19 patients with new neurological complications survived to hospital discharge. Data reported that 50% of COVID-19 patients had impaired cognition, and 47% were unable to return to work after 6 months. Abnormalities in functional outcomes, activities of daily living, anxiety, depression, and sleep occurred in more than 90% of COVID-19 patients 6 months after hospitalization. According to multivariable analysis, patients with neurological complications during index hospitalization had significantly worse 6-month functional outcomes than those who did not.

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