A phase III study evaluating the efficacy and safety of remimazolam (CNS 7056) compared with placebo and midazolam in patients undergoing colonoscopy
Gastrointestinal Endoscopy May 07, 2018
Rex DK, et al. - This randomized double-blind study comparatively analyzed the effects of remimazolam to placebo for outpatient colonoscopy. Patients were given 50 to 75 μg of fentanyl before receiving study medications. Data demonstrated that subjects administered remimazolam received less fentanyl, had a faster recovery of neuropsychiatric function, were ready for discharge faster, and felt back to normal faster compared to patients with both placebo and midazolam. Therefore, it was deduced that remimazolam could be safely administered under the supervision of endoscopists for outpatient colonoscopy and allows faster recovery of neuropsychiatric function compared with placebo (midazolam rescue) and midazolam.
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