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The influence of indentation deformity on outcomes with intralesional collagenase clostridium histolyticum monotherapy for Peyronie disease

Urology Feb 18, 2020

Ziegelmann MJ, et al. - This study was attempted to distinguish patient-specific factors correlated with patient-reported improvements in functional outcomes after intralesional Collagenase Clostridium histolyticum for Peyronie's Disease (PD). Researchers retrospectively examined the prospectively-maintained CCH registry. A total of 86 individuals were included who underwent CCH monotherapy. Although no association was found between baseline curvature and relative (%) improvement, greater baseline curvature was correlated with greater absolute improvements in curvature. Individuals with baseline indentation/hourglass were less likely to present that CCH prevented the requirement for surgery. The outcomes suggested that baseline indentation/hourglass deformity and curve improvement < 15o are correlated with less favorable functional improvements such as preventing the requirement for surgery and improving penetration.
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