Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis

Arthritis Research & Therapy Sep 11, 2019

Bihlet AR, Byrjalsen I, Bay-Jensen A, et al. - Baseline data of two randomized clinical trials in patients with radiographic OA and presence of pain were investigated post hoc in order to examine the relationship between OA knee joints at various radiographic stages and pain classes with levels of uCTX-II and biomarkers of bone resorption and formation. Levels of uCTX-II were independently correlated with the radiographic severity of OA and pain intensity. CTX-II was related to weight-bearing pain, though not with non-weight-bearing pain, independent of covariates. According to the radiographic severity of single joints, Bilateral OA knee joints seemed to contribute to uCTX-II levels in an incremental manner. Thus, the data imply that biomarker variations between genders should be considered when assessing these markers in the context of structural features of OA.
Go to Original

Sign-up to continue reading. It is free & takes less than 2 mins

  • 45 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Free & unlimited access to original articles and quizzes
  • Nonloggedinlock icon
    Secure: we never sell your data
This article is only available to members. Are you a doctor? Click here to signup for free.
Try M3 India / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay