Walker KA, Sharrett AR, Wu A, et al. - Through this prospective cohort study comprised of 4,761 individuals with 24-year follow-up and blood pressure (BP) measurements at midlife and late-life, researchers investigated the correlation of midlife to late-life BP patterns with subsequent dementia, mild cognitive impairment, and cognitive deterioration. Significantly increased risk of subsequent dementia was observed in individuals in the midlife and late-life hypertension group and in midlife hypertension and late-life hypotension group vs those who continued to be normotensive. Sustained hypertension in midlife was associated with dementia risk, despite late-life BP. Only individuals with midlife hypertension and late-life hypotension had a greater risk of mild cognitive impairment in comparison with those who were normotensive in midlife and late-life. No important relationship between BP patterns and late-life cognitive alterations were noted. Overall, sustained hypertension in midlife to late-life and a pattern of midlife hypertension and late-life hypotension, compared with midlife and late-life normal BP, were correlated with elevated risk for subsequent dementia.