Associations of serum uric acid with total and cause-specific mortality: Findings from individuals and pooling prospective studies

Atherosclerosis Jul 25, 2019

Mazidi M, et al. - Researchers used the National Health and Nutrition Examination Surveys (1999–2010) to prospectively assess the link between serum uric acid (SUA) and risk of total and cause specific (coronary heart disease [CHD], cerebrovascular, and cancer) mortality. To determine pooled links of SUA with all-cause and cause-specific death, they carried out a systematic review and meta-analysis of cohort studies. This study included 21,025 participants (mean age: 47.6 years; 48.7% men). A follow-up of 144 months was performed. A 10% and 8% greater risk of CHD and stroke mortality, respectively, was noted in participants in the highest quartile of SUA, according to adjusted models. The risk of total, CHD, and stroke mortality was predicted by SUA, as revealed in the meta-analysis. Overall, mortality was adversely influenced by SUA, which was especially evident in older (aged > 50 years) women.

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