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Clinical predictors of renal non-recovery in acute respiratory distress syndrome

BMC Nephrology Jul 17, 2019

Panitchote A, et al. - In this single center retrospective cohort study, researchers investigated the factors that predict renal non-recovery in acute respiratory distress syndrome (ARDS) patients. The patients with preexisting chronic kidney disease or intensive care unit stay < 24 h were removed from the study. Using the Kidney Disease Improving Global Outcomes 2012 guidelines, acute kidney injury (AKI) staging was defined. The definition of renal non-recovery included death, dialysis dependence, serum creatinine ≥1.5 times the baseline, or urine output < 0.5 mL/kg/h more than 6 h. Renal non-recovery in ARDS patients was predicted by a higher stage of AKI, delayed onset of AKI, a history of malignancy, septic shock, and a higher tidal volume on day 1–3 of ARDS. The factors that were found to be related to renal non-recovery among survivors included a higher stage of AKI, delayed onset of AKI, and a history of malignancy.
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