Gallstone disease and type 2 diabetes risk: A Mendelian randomization study

Hepatology Mar 14, 2019

Wang F, et al. - A sum of 16,299 participants were researched over to examine the relationship between gallstone disease (GSD) and type 2 diabetes risk, using a Mendelian randomization analysis. Researchers diagnosed GSD by abdominal B-type ultrasound inspection and type 2 diabetes according to the criteria of the American Diabetes Association. From 2008 to 2013 ie, median 4.6 years, they recorded 1110 incident type 2 diabetes cases during 73,895 person-years of follow-up. They noted an association of each 1 SD (0.23) increment in the weighted GRS with a 17% increase of type 2 diabetes risk without statistical significance. Hence, they supported a positive but not a causal relationship between GSD and type 2 diabetes risk.

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