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This Alzheimer's Day: Do Not Forget to Take the Quiz!

M3 India Newsdesk Sep 21, 2022

Alzheimer's disease is a brain ailment that gradually impairs thinking and memory abilities as well as the capacity to do even the most basic tasks. This World Alzheimer's day, let's learn more about the disease and its management.

 

World Alzheimer's Day: MCQ Challenge!

  1. Which among the biomarkers of Alzheimer’s disease is not a marker of neurodegeneration?
  1. Hippocampal volume is typically preserved in which form of Alzheimer’s disease?

  1. A 53 year-old woman presented with a 2-year h/o progressive decline in her ability to find words and pronounce them correctly. She could not repeat or understand sentences when they were too long. O/E: Mini-Mental State Examination(MMSE) score of 17/30. She could not do the serial reversals and could not come up with the word watch. Memory examination was intact on delayed recall. She showed word-finding pauses, hesitations, and frequent phonemic paraphasic errors but no agrammatism or difficulty comprehending single words or simple commands. However, she had prominent difficulty with repetition, quickly breaking down if a sentence was more than a few words. She was unable to give the names of more than seven animals in 1 minute or name more than seven of 20 objects. On the naming task, she made phonemic paraphasic errors, such as 'Campbell' for 'camel' and 'volcan' for 'volcano'. The rest of the neurologic examination was normal. What is the most likely diagnosis?
  1. A 46-year-old man, previously healthy, presented with h/o gait and balance difficulty for 3 years. C/o numbness of toes while running for 4 years and it has gradually spread to his knees, worsening symptoms with fatigue and running. C/o difficulty in emptying bladder and bladder urgency for 1 year. O/E: Increased tone seen and 4/5 power in dorsiflexion of his right foot with increased tone bilaterally. Coordination was intact but his gait was consistent with right foot drop and vibration sensations were altered in both lower extremities. Generalised hyperreflexia present with upgoing plantar. MRI image shows more than 2 hyperintense lesions in the spinal cord and 2-3 t2 hyperintense lesions in the periventricular and infratentorial area. What is the diagnosis?

 

  1. Episodic memory is typically spared in _________.
  1. A 2-year-old child was presented with severe psychomotor retardation, dystonia, ataxia and microcephaly with h/o seizures since 3 months of age. He has a typical history of seizure clusters and status epilepticus during fasting. Which among the following gene mutation is associated with this condition?
  1. Which of the following treatment modality is NOT correlating with genetic epilepsy syndrome?

 

  1. Which of the following statements regarding Anti IgLON5 disease is INCORRECT?

 

  1. Which of the following epilepsy syndrome does NOT have onset at the neonatal period?

 

  1.  A 2-year-old child with h/o febrile seizures now presents with generalist tonic-clonic and hemiconvulsive seizures. He also had myoclonic jerks with psychomotor regression and features of attention deficit hyperactivity disorder. Which of the following gene is strongly associated with this condition?

 

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