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Liquid Biopsies in Lung Cancer Management: MCQ Challenge

M3 India Newsdesk Feb 20, 2024

These multiple-choice questions guide doctors in understanding the applications of liquid biopsy in managing non-small cell lung cancer (NSCLC). It emphasises the utility of liquid biopsy in situations where tissue biopsy is challenging or unavailable.


Lung cancer management: MCQ challenge

  1. A 62-year-old patient with a history of heavy smoking is diagnosed with advanced non-small cell lung cancer (NSCLC). Initial tissue biopsy testing reveals an EGFR exon 19 deletion mutation. The patient begins treatment with an EGFR tyrosine kinase inhibitor (TKI). Which of the following is a potential application of liquid biopsy in this patient's management?

  1. A 58-year-old patient is diagnosed with metastatic non-small cell lung cancer (NSCLC). A tissue biopsy cannot be obtained due to the tumour's inaccessible location. The patient is interested in targeted therapy options. How can liquid biopsy be helpful in this patient's management?

  1. A 70-year-old former smoker is diagnosed with early-stage non-small cell lung cancer (NSCLC). The tumour is surgically removed, and the patient undergoes follow-up surveillance with regular imaging. In which way might liquid biopsy be potentially useful in this patient's care?

  1. A 65-year-old patient with advanced non-small cell lung cancer (NSCLC) has been receiving immunotherapy for several months. Imaging scans show a mixed response, with some areas of tumour shrinkage and other areas of stability. How might liquid biopsy be used to assist in this patient's treatment evaluation?

  1. A patient with metastatic non-small cell lung cancer (NSCLC) was initially found to have an ALK rearrangement on tissue biopsy. After progressing on an ALK inhibitor, a repeat tissue biopsy is considered risky due to the tumour location. How could liquid biopsy be used in this scenario?
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