1.  A 55-year-old woman with a 10-year history of type 2 diabetes presents with fatigue, weight gain, and constipation despite good glycemic control. The clinician suspects that this patient has a concurrent thyroid disorder. Which of the following thyroid function tests is most likely to be abnormal?

• Increased T3
• Increased T4
• Increased TSH
• Decreased TSH

2. In a patient with Graves' disease, which of the following statements is incorrect regarding the effects of hyperthyroidism on glucose metabolism?

• Increased GLUT4 gene expression
• Enhanced beta cells response to glucose
• Reduced rate of insulin degradation
• Increased secretion of glucagon

3. The optimal screening strategy for patients with type 1 diabetes (T1D) who are clinically euthyroid is?

• TSH done every year
• TSH done every 6 months
• Full thyroid function test done every year
• Full thyroid function test done every 6 months

4. Which of the following medications used in the treatment of diabetes can potentially aggravate thyroid-associated orbitopathy?

• Metformin
• Sitagliptin
• Pioglitazone
• Liraglutide

5. Regarding patients with diabetes and comorbid Grave’s disease, which of the following statements is correct?

• T1DM is more common in patients with Graves’ orbitopathy.
• Graves’ orbitopathy is more frequent and severe in Graves’ disease patients with T2DM.
• Diabetic patients with Graves’ orbitopathy have a higher incidence of dysthyroid optic neuropathy.
• All of the above.