• Profile
Close

Nano bubbles filled with drug may kill cancer cells: Study

IANS Jul 17, 2018

In a step further to identify range of cancer treatments available to patients, scientists have developed drug-filled nano bubbles triggered in the body by X-rays which may help kill the malignant cells.

 

 

 


The tiny bubbles, known as liposomes, are commonly used in pharmacology to encapsulate drugs, making them more effective in the treatment of disease and researchers have now been able to engineer these liposomes to discharge their drug cargo on-demand, once activated by standard X-rays. Initial testing has shown this technique to be highly efficient in killing bowel cancer cells. "The development and application of various nanomaterial designs for drug delivery is currently a key focus area in nanomedicine," said lead author Wei Deng, fro ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Australia.

"Liposomes are already well established as an extremely effective drug-delivery system. Made out of similar material as cell membranes, these 'bubbles' are relatively simple to prepare, can be filled with appropriate medications and then injected into specific parts of the body. The issue however, is in controlling the timely release of the drug from the liposome," Deng added.

For the study, published in the journal Nature Communications, the team embeded gold nanoparticles and the photo-sensitive molecule verteporfin into the wall of the liposome, in a laboratory setting. The X-ray radiation caused the verteporfin to react and produce highly reactive singlet oxygen which destabilisesdthe liposomal membrane, causing the release of the drug, Deng explained.

"The gold nanoparticles are added into the mix as they focus the X-ray energy. This enhances the singlet oxygen generation and hence improves the speed of the membrane breakup," she added. The liposomes were filled with chemotherapy drug called doxorubicin, which killed the cancer cells far more effectively than without X-ray triggering. Thus, controlling the timely release of the drug from the bubble is very crucial, Deng said.

Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay