• Profile
Close

Exercise can help boost memory through bone hormone: Study

IANS Oct 25, 2018

Researchers have identified a naturally occurring bone hormone that can potentially reverse memory loss in the ageing brain through exercise.



The study on the hormone osteocalcin lends new insight into how lifestyle changes that affect the body, such as exercise, could positively affect the brain. "Nearly everyone will experience age-related memory loss in their lifetime, so it is incredibly important to understand its causes and identify ways to mitigate it," said Eric R. Kandel, Professor at the Columbia University.

"With today's study, we are not only building a detailed understanding of how age-related memory loss originates in the brain, we've shown how osteocalcin interacts with key proteins in the brain to boost memory." For many years, memory loss was treated as a singular disorder. But scientists have now begun to realise that Alzheimer's disease, begins in a part of the brain called the entorhinal cortex, which lies at the foot of the hippocampus. 

On the other hand, age-related memory loss, begins within the hippocampus itself, in a region called the dentate gyrus, Kandel said. Kandel's team identified a deficiency in a protein called RbAp48 protein, a significant contributor to age-related memory loss but not Alzheimer's. The protein levels decline with age, both in mice and in people.

In a series of experiments, reported in the journal Cell Reports, the team found that RbAp48 controls the expression levels of two other proteins regulated from osteocalcin. If RbAp48 function is inhibited, osteocalcin infusions have no effect on the animals' memory. Osteocalcin needs RbAp48 to kick-start the process. These findings also provide further evidence that exercise may be the best way to stave off or even treat, age-related memory loss in people. Studies in mice showed that moderate exercise, such as walking, triggers the release of osteocalcin in the body.

Only Doctors with an M3 India account can read this article. Sign up for free.
  • 55 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Unlimited access to original articles by experts
  • Nonloggedinlock icon
    Secure: we never sell your data
  • Signing up takes less than 2 mins
Try M3 India / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay